In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608.

@article{Zurenko1990InVA,
  title={In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608.},
  author={Gary E. Zurenko and Sarah E. Truesdell and Betty H. Yagi and Robert J Mourey and Alice L. Laborde},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 5},
  pages={884-8}
}
U-78608, a new monocarbam antibiotic, was evaluated for in vitro activity against 312 clinical isolates of aerobic and anaerobic bacteria and subjected to several in vitro biochemical tests characterizing its interactions with beta-lactamases and penicillin-binding proteins (PBPs). The antibacterial activity of the compound was compared directly with those of SQ 83,360 (pirazmonam) and aztreonam. U-78608, SQ 83,360, and aztreonam had generally poor activity against gram-positive aerobic… CONTINUE READING