In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi.

  title={In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi.},
  author={J. Bua and A. M. Ruiz and M. Potenza and L. Fichera},
  journal={Bioorganic & medicinal chemistry letters},
  volume={14 18},
  • J. Bua, A. M. Ruiz, +1 author L. Fichera
  • Published 2004
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • Cyclosporin A (CsA) nonimmunosuppressive analogs were evaluated against Trypanosoma cruzi and on TcCyP19, a cyclophilin of 19 kDa. Two out of eight CsA analogs, H-7-94 and F-7-62 showed the best anti-parasitic effects on all in vitro assays. Their IC(50) values were 0.82 and 3.41 microM, respectively, compared to CsA IC(50) value 5.39 microM on epimastigote proliferation; and on trypomastigote lysis their IC(50) values were 0.97 and 2.66 microM compared to CsA IC(50) value 7.19 microM. H-7-94… CONTINUE READING
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