In vitro anti-mesothelioma activity of cisplatin–gemcitabine combinations: evidence for sequence-dependent effects

@article{Zanellato2010InVA,
  title={In vitro anti-mesothelioma activity of cisplatin–gemcitabine combinations: evidence for sequence-dependent effects},
  author={Ilaria Zanellato and Carla Doriana Boidi and Guido Lingua and P G Betta and Sara Orecchia and Elena Monti and Domenico Osella},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2010},
  volume={67},
  pages={265-273}
}
The present study addresses the optimization of gemcitabine–cisplatin protocols currently adopted in the clinical management of malignant pleural mesothelioma (MPM), using cell lines derived from different histological subtypes of MPM as an in vitro model. MPM cell lines were exposed either to single drugs or to their combinations, using a fixed dose ratio. Possible mechanisms for synergistic interactions were investigated by cell cycle analysis, western blot analysis of p53 phosphorylation… CONTINUE READING

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