In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesisb

@article{Landa2009InVA,
  title={In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesisb},
  author={Premysl Landa and Ladislav Kokoska and Marie Pribylova and Tom{\'a}s Vanek and Petr Mar{\vs}{\'i}k},
  journal={Archives of Pharmacal Research},
  year={2009},
  volume={32},
  pages={75-78}
}
Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E2 catalysed by COX-2 with an IC50 value of 0.8 μM what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 μM and 0.8 μM, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 μM for carvacrol), which suggests non-selective inhibition of… CONTINUE READING
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