In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives.

  title={In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives.},
  author={Venkateswarlu Korthikunta and Jyotsana Pandey and Rohit Singh and Rohit Kumar Srivastava and Arvind K. Srivastava and Akhilesh K Tamrakar and Narender Tadigoppula},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={22 1},
The nonproteinogenic amino acid, 4-hydroxyisoleucine (1) has been isolated in large quantities from the fenugreek (T. foenum-graecum) seeds. Few novel derivatives (3-11 and 13-18) were prepared from the naturally occurring 4-hydroxyisoleucine (1) and screened for their in vitro glucose uptake stimulatory effect in L-6 skeletal muscle cells. The derivatives 6, 7, 8, 10 and 11 exhibited better glucose uptake stimulatory activity than parent compound, 4-hydroxyisoleucine at 5 and 10µM… CONTINUE READING