In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2.

@article{Guillaume2015InVA,
  title={In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2.},
  author={Carole Guillaume and Christine Payr{\'e} and Ikram Jemel and Louise Jeammet and Sofiane Bezzine and Gajendra S Naika and James M. Bollinger and Philippe Grellier and Michael H Gelb and Joseph Schr{\'e}vel and G{\'e}rard Lambeau and Christiane Deregnaucourt},
  journal={Infection and immunity},
  year={2015},
  volume={83 6},
  pages={
          2453-65
        }
}
We have previously shown that secreted phospholipases A2 (sPLA2s) from animal venoms inhibit the in vitro development of Plasmodium falciparum, the agent of malaria. In addition, the inflammatory-type human group IIA (hGIIA) sPLA2 circulates at high levels in the serum of malaria patients. However, the role of the different human sPLA2s in host defense against P. falciparum has not been investigated. We show here that 4 out of 10 human sPLA2s, namely, hGX, hGIIF, hGIII, and hGV, exhibit potent… CONTINUE READING
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