In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata

@article{Sharma2004InVA,
  title={In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata},
  author={Vinay Kumar Sharma and Jinsuk Choi and Niti Sharma and Mieyoung Choi and Sung-Yum Seo},
  journal={Phytotherapy Research},
  year={2004},
  volume={18}
}
The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5‐(hydroxymethyl)‐2‐furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L‐DOPA. On the basis of these findings some related analogues were also tested for their anti‐tyrosinase activity, in order to gain more insight into structure and activity… Expand
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