In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata

  title={In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata},
  author={Vinay Kumar Sharma and Jinsuk Choi and Niti Sharma and Mieyoung Choi and Sung-Yum Seo},
  journal={Phytotherapy Research},
The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5‐(hydroxymethyl)‐2‐furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L‐DOPA. On the basis of these findings some related analogues were also tested for their anti‐tyrosinase activity, in order to gain more insight into structure and activity… Expand
5-Hydroxymethyl-2-Furfural (HMF) – Heat-Induced Formation, Occurrence in Food and Biotransformation – a Review
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This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades. Expand
Inhibitory Effects of Quercetin and Kaempferol as two Propolis Derived Flavonoids on Tyrosinase Enzyme
inhibitors. Materials and Methods: In this work, the effects of quercetin and kaempferol as propolis-derived compounds on activity of mushroom tyrosinase (MT) were studied. These flavonoids showedExpand
Furan inhibitory activity against tyrosinase and impact on B16F10 cell toxicity.
Results expose differential toxicity of these furan derivatives, which indicates a piece of evidence that furan inhibition activity may be related to its toxicity against B16F10 cells. Expand
2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats
Five distinct organic compounds with protected and unprotected phenolic hydroxyl groups were screened for their α-glucosidase inhibitory potential. Of these compounds, 2,4,6-trihydroxybenzaldehydeExpand
The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)
Of the bioactive compounds, the chemistry of the polysaccharides as major bioactive components primarily the β-glucan with side branches of β-(1→6)-glucosyl units are discussed, while small molecular weight compounds include terpenoids and alkaloids. Expand
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Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights
5-Hydroxymethylfurfural (HMF) is a natural product derived from the degradation of sugars in e.g. milk, honey and raisins. Recent studies have shown that this compound has several beneficialExpand


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A series of alpha,beta-unsaturated aldehydes characterized from the olive Olea europaea L. (Oleaceae) oil flavor was found to inhibit the oxidation of L-3, 4-dihydroxyphenylalanine catalyzed by mushroom tyrosinase, and the inhibition kinetics analyzed by a Lineweaver-Burk plot found that they are noncompetitive inhibitors. Expand
Tyrosinase Inhibitors from Cumin
Cuminaldehyde (p-isopropylbenzaldehyde) was identified as a potent mushroom tyrosinase inhibitor from cumin, a common food spice. This benzaldehyde derivative was found to inhibit the oxidation ofExpand
2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.
2-hydroxy-4-methoxybenzaldehyde was characterized as the principal tyrosinase inhibitor from three East African medicinal plants, the root of Mondia whitei (Hook) Skeels (Asclepiaceae), theroot of Rhus vulgaris Meikle (Anacardiaceae), and the bark of Sclerocarya caffra Sond (AnACardiaceae). Expand
Polysaccharides in fungi. XIII. Antitumor activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auricula-judae, and Auricularia species.
A mannan and water-soluble glucans from Dictyophora indusiata, a water-insoluble glucan from Ganoderma japonicum, a galactomannan from Cordyceps cicadae, and acidic heteroglycans from Auricularia auricula-judae and auricularia species were tested for antitumor activity against subcutaneously implanted sarcoma 180 in mice by intraperitoneal administration. Expand
Detection and determination of interfering 5–hydroxymethylfurfural in the analysis of caramel–coloured pharmaceutical syrups
A limit test for 5–HMF in caramel was developed, which is sensitive and selective for the detection and determination of trace amounts of 5-hydroxymethylfurfural without interference from the brown products of caramel. Expand
Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi.
T-2-HN has more potent anti-inflammatory activity than phenylbutazone in the above two inflammatory models and it is clear that anti- inflammatory effect arises from the polysaccharide itself. Expand
Monoterpene-alcohols from a mushroom Dictyophora indusiata
Abstract Five monoterpene-alcohols were isolated from a mushroom Dictyophora indusiata , one of which was identified as 3,7-dimethyl-1,6-octadiene-3,4-diol and its absolute configuration wasExpand
5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione.
The results suggest that HMF does not pose a serious health risk, even though the highest concentrations in specific foods approach the biologically effective concentration range in cell systems. Expand
The chemistry of melanin; mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase.
  • H. S. Mason
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1948
It was possible to show that a rearrangement of the red pigment does occur during the enzymic oxidation, that synthetic dihydroxyphenylalanine melanin is probably a polymer of indoled, 6-quinone, and that the inferred o-quinonoid formulation of thered pigment is correct. Expand
The biochemistry and control of enzymatic browning
Current approaches to understanding and controlling enzymatic browning are presented, with special focus on the use of antisense RNA as a control method. Expand