In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata

  title={In vitro anti‐tyrosinase activity of 5‐(hydroxymethyl)‐2‐furfural isolated from Dictyophora indusiata},
  author={Vinay Kumar Sharma and Jinsuk Choi and Niti Sharma and Mieyoung Choi and Sung-Yum Seo},
  journal={Phytotherapy Research},
The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5‐(hydroxymethyl)‐2‐furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L‐DOPA. On the basis of these findings some related analogues were also tested for their anti‐tyrosinase activity, in order to gain more insight into structure and activity… 
5-Hydroxymethyl-2-Furfural (HMF) – Heat-Induced Formation, Occurrence in Food and Biotransformation – a Review
Abstract The chemical structure of 5-hydroxymethyl-2-furfural (HMF), its physicochemical properties and reactions that lead to the synthesis of HMF were discussed. Special attention was paid to HMF
Tyrosinase inhibitors of Galla Rhois and its derivative components
This is the first HPLC analysis containing ascorbic acid, 5-HMF and arbutin, Galla Rhois exert varying degrees of inhibition on tyrosinase-dependent and these result suggest that GallaRhois may serve as candidates for depigmenting agents.
Sardinian honeys as sources of xanthine oxidase and tyrosinase inhibitors
Honey from Arbutus flowers had the highest antioxidant activity followed by Eucalyptus and Thistle ones, which showed good tyrosinase and xanthine oxidase inhibition properties and could have a great potential as antioxidant sources for pharmaceutical and cosmetic applications.
A comprehensive review on tyrosinase inhibitors
This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.
Inhibitory Effects of Quercetin and Kaempferol as two Propolis Derived Flavonoids on Tyrosinase Enzyme
In general, quercetin and kaempferol can be used as good candidates in melanogenesis inhibition and should be considered as good blockers of enzyme activity in hyper pigmentation and clinical application.
Furan inhibitory activity against tyrosinase and impact on B16F10 cell toxicity.
2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats
2,4,6-trihydroxybenzaldehyde (THB) showed the strongest noncompetitive α-glucosidase inhibition and the most powerful antioxidant activity (DPPH assay) in vitro and in in vivo studies.
The Chemistry, Pharmacology and Therapeutic Potential of the Edible Mushroom Dictyophora indusiata (Vent ex. Pers.) Fischer (Synn. Phallus indusiatus)
Of the bioactive compounds, the chemistry of the polysaccharides as major bioactive components primarily the β-glucan with side branches of β-(1→6)-glucosyl units are discussed, while small molecular weight compounds include terpenoids and alkaloids.
Hydroxymethyl furfural (HMF) is one of important intermediates formed in Maillard reaction and caramelization. It was found that HMF existed in many Chinese herbal medicines (CHMs) and accumulated
Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights
5-Hydroxymethylfurfural (HMF) is a natural product derived from the degradation of sugars in e.g. milk, honey and raisins. Recent studies have shown that this compound has several beneficial


Tyrosinase inhibitory activity of the olive oil flavor compounds.
A series of alpha,beta-unsaturated aldehydes characterized from the olive Olea europaea L. (Oleaceae) oil flavor was found to inhibit the oxidation of L-3, 4-dihydroxyphenylalanine catalyzed by mushroom tyrosinase, and the inhibition kinetics analyzed by a Lineweaver-Burk plot found that they are noncompetitive inhibitors.
Tyrosinase Inhibitors from Cumin
Cuminaldehyde (p-isopropylbenzaldehyde) was identified as a potent mushroom tyrosinase inhibitor from cumin, a common food spice. This benzaldehyde derivative was found to inhibit the oxidation of
2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.
2-hydroxy-4-methoxybenzaldehyde was characterized as the principal tyrosinase inhibitor from three East African medicinal plants, the root of Mondia whitei (Hook) Skeels (Asclepiaceae), theroot of Rhus vulgaris Meikle (Anacardiaceae), and the bark of Sclerocarya caffra Sond (AnACardiaceae).
Polysaccharides in fungi. XIII. Antitumor activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auricula-judae, and Auricularia species.
A mannan and water-soluble glucans from Dictyophora indusiata, a water-insoluble glucan from Ganoderma japonicum, a galactomannan from Cordyceps cicadae, and acidic heteroglycans from Auricularia auricula-judae and auricularia species were tested for antitumor activity against subcutaneously implanted sarcoma 180 in mice by intraperitoneal administration.
Detection and determination of interfering 5–hydroxymethylfurfural in the analysis of caramel–coloured pharmaceutical syrups
A limit test for 5–HMF in caramel was developed, which is sensitive and selective for the detection and determination of trace amounts of 5-hydroxymethylfurfural without interference from the brown products of caramel.
Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi.
T-2-HN has more potent anti-inflammatory activity than phenylbutazone in the above two inflammatory models and it is clear that anti- inflammatory effect arises from the polysaccharide itself.
5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione.
The chemistry of melanin; mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase.
  • H. S. Mason
  • Chemistry, Biology
    The Journal of biological chemistry
  • 1948
It was possible to show that a rearrangement of the red pigment does occur during the enzymic oxidation, that synthetic dihydroxyphenylalanine melanin is probably a polymer of indoled, 6-quinone, and that the inferred o-quinonoid formulation of thered pigment is correct.