In vitro angiogenesis induced by tumor-endothelial cell co-culture in bilayered, collagen I hydrogel bioengineered tumors.

@article{Szot2013InVA,
  title={In vitro angiogenesis induced by tumor-endothelial cell co-culture in bilayered, collagen I hydrogel bioengineered tumors.},
  author={Christopher S. Szot and Cara F. Buchanan and Joseph Freeman and Marissa Nichole Rylander},
  journal={Tissue engineering. Part C, Methods},
  year={2013},
  volume={19 11},
  pages={864-74}
}
Although successful remission has been achieved when cancer is diagnosed and treated during its earliest stages of development, a tumor that has established neovascularization poses a significantly greater risk of mortality. The inability to recapitulate the complexities of a maturing in vivo tumor microenvironment in an in vitro setting has frustrated attempts to identify and test anti-angiogenesis therapies that are effective at permanently halting cancer progression. We have established an… CONTINUE READING

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