In vitro andin vivo studies of native and dextran-modified hyaluronidase

@article{Maksimenko2004InVA,
  title={In vitro andin vivo studies of native and dextran-modified hyaluronidase},
  author={Alexander V Maksimenko and Olga Y Konovalova and V. P. Berdichevskii and O. G. Arkhipova and Vladimir Torchilin},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={102},
  pages={1545-1547}
}
Enzume preparations have justified their use as effective therapeutic agents [8]~ However, their widespread use in medical practice is delayed partly by the low stability of native enzymes under physiological conditions [2]. This limitation can be overcome by modification of enzymes, which can substantially enhance their stability [i]. That this is a… CONTINUE READING