In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer.

  title={In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer.},
  author={Shiby Paul and Cassia Suemi Mizuno and Hong Jin Lee and Xi Zheng and Sarah Chajkowisk and John M. Rimoldi and Allan H. Conney and Nanjoo Suh and Agnes M Rimando},
  journal={European journal of medicinal chemistry},
  volume={45 9},
Based on the potential of resveratrol as a colon cancer chemopreventive agent, a set of 26 stilbenes were synthesized and tested against the colon cancer cell lines HT-29 and Caco-2. (Z)-4-(3,5-Dimethoxystyryl)aniline (4), (Z)-methyl-4-(3,5-dimethoxystyryl)benzoate (6), and (Z)-1,3-dimethoxy-5-(4-methoxystyryl)benzene (10) showed strong inhibitory activity in vitro. In vivo studies using HT-29 xenografts in immunodeficient mice were conducted with 4, 6 and 10, together with their corresponding… CONTINUE READING
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