In vitro and in vivo studies of streptomycin-resistant, penicillin-susceptible streptococci from patients with infective endocarditis.

@article{Enzler1987InVA,
  title={In vitro and in vivo studies of streptomycin-resistant, penicillin-susceptible streptococci from patients with infective endocarditis.},
  author={Mark Enzler and Mark S. Rouse and Nancy K Henry and Joseph E. Geraci and Walter R. Wilson},
  journal={The Journal of infectious diseases},
  year={1987},
  volume={155 5},
  pages={954-8}
}
The combination of penicillin and streptomycin did not act synergistically in vitro against three streptomycin-resistant strains (MIC, greater than or equal to 1,000 micrograms of streptomycin/ml) of penicillin-susceptible streptococci. Using a model of experimental infective endocarditis, we infected rabbits with a control streptomycin-susceptible strain, with an intermediately streptomycin-resistant strain (MIC, 1,000 micrograms/ml), and with a highly streptomycin-resistant strain (MIC… CONTINUE READING