In vitro and in vivo studies of antagonistic effects of human growth hormone analogs.

Abstract

A bovine growth hormone (bGH) analog, bGH-G119R, has been shown to act as a functional antagonist of GH activity both in vitro and in vivo. In the present study, human (h) GH analogs with alterations in the third alpha-helix (G120A, G120R) and N terminus (I4A) were generated. These two regions have been reported to form binding site 2 in hGH, which is… (More)

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@article{Chen1994InVA, title={In vitro and in vivo studies of antagonistic effects of human growth hormone analogs.}, author={W. Y. Chen and N. Y. Chen and J. Yun and T. E. Wagner and John J. Kopchick}, journal={The Journal of biological chemistry}, year={1994}, volume={269 32}, pages={20806} }