In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues.

@article{Julien2012InVA,
  title={In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues.},
  author={Michel Julien and Richard G Kay and Patric J. D. Delhanty and Soraya Allas and Riccarda Granata and Chris W Barton and Scott Constable and Ezio Ghigo and Aart J van der Lely and Thierry Abribat},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2012},
  volume={47 4},
  pages={625-35}
}
Ghrelin, an endocrine hormone predominantly produced by the stomach, exists in acylated and unacylated forms in the circulation. Unacylated ghrelin (UAG), the more abundant form in blood, possesses similar, independent or opposite physiological actions as acylated ghrelin (AG). AZP502, a linear 8-amino acid peptide from the central region of UAG (UAG(6-13)), and its full (AZP531) and partially (AZP533) cyclised derivatives, exhibit the same pharmacological profile as UAG both in vitro and in… CONTINUE READING

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Unacylated ghrelin fragments promote survival of pancreatic b-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats

  • R. Granata, F. Settani, +9 authors E. Ghigo
  • J. Med. Chem
  • 2012
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