In vitro and in vivo reversal of cancer cell multidrug resistance by the semi-synthetic antibiotic tiamulin.

@article{Baggetto1998InVA,
  title={In vitro and in vivo reversal of cancer cell multidrug resistance by the semi-synthetic antibiotic tiamulin.},
  author={Loris G. Baggetto and M Dong and Jeanine Bernaud and L. Manzano Espinosa and Dominique Rigal and Robert Bonvallet and Eric Marthinet},
  journal={Biochemical pharmacology},
  year={1998},
  volume={56 9},
  pages={1219-28}
}
A large number of multidrug resistance (MDR) modulators, termed chemosensitizers, have been identified from a variety of chemicals, but most have been proven to be clinically toxic. Low concentrations of the pleuromutilin-derived semi-synthetic antibiotic tiamulin (0.1 to 10 microM) sensitized the three highly resistant P-glycoprotein (Pgp)-overexpressing tumor cell lines P388 (murine lymphoid leukemia), AS30-D (rat hepatoma), CEM (human lymphoblastic leukemia), and the barely resistant AS30-D… CONTINUE READING

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