In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201.

  title={In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201.},
  author={S Huerta and Xiaohuan Gao and Edward H. Livingston and Payal Kapur and Haizhou Sun and Thomas Anthony},
  volume={148 2},
BACKGROUND The response to neoadjuvant chemoradiation in rectal cancer is variable and unpredictable. Resistance to chemoradiation has been directly correlated with the levels of the inhibitors of apoptosis (IAPs) in several malignancies. Because smac-DIABLO is a pro-apoptotic gene product that directly inhibits the activity of the IAPs, molecules with similar activity might radiosensitize rectal tumors with phenotypes that express high levels of IAPs. This study was undertaken to assess the… CONTINUE READING


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