In vitro and in vivo protein sampling by combined microdialysis and ultrafiltration.

  title={In vitro and in vivo protein sampling by combined microdialysis and ultrafiltration.},
  author={Alan John Rosenbloom and Robert L Ferris and David M Sipe and Sharon A. Riddler and Nancy C Connolly and Keiko Abe and Theresa L Whiteside},
  journal={Journal of immunological methods},
  volume={309 1-2},
Cytokines, chemokines and growth factors regulate inflammation, resistance to infection and tissue repair. Understanding their function within tissues is a priority in evolving therapy for a number of disease processes. Yet, the existence of complex networks of these factors in the tissue microenvironment has made understanding of their interactions difficult. We demonstrate the capability of microdialysis probes to recover small proteins efficiently in vitro. Further we show that microdialysis… CONTINUE READING

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