In vitro and in vivo properties of BAL30376, a β-lactam and dual beta-lactamase inhibitor combination with enhanced activity against Gram-negative Bacilli that express multiple β-lactamases.

Abstract

BAL30376 is a triple combination comprising a siderophore monobactam, BAL19764; a novel bridged monobactam, BAL29880, which specifically inhibits class C β-lactamases; and clavulanic acid, which inhibits many class A and some class D β-lactamases. The MIC(90) was ≤ 4 μg/ml (expressed as the concentration of BAL19764) for most species of the… (More)
DOI: 10.1128/AAC.01370-10

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Cite this paper

@article{Page2011InVA, title={In vitro and in vivo properties of BAL30376, a β-lactam and dual beta-lactamase inhibitor combination with enhanced activity against Gram-negative Bacilli that express multiple β-lactamases.}, author={Malcolm G. P. Page and Clothilde Dantier and Eric Desarbre and B{\'e}rang{\`e}re Gaucher and Klaus Gebhardt and Anne H Schmitt-Hoffmann}, journal={Antimicrobial agents and chemotherapy}, year={2011}, volume={55 4}, pages={1510-9} }