In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action.

@article{Lehtimki2008InVA,
  title={In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action.},
  author={Jyrki Lehtim{\"a}ki and Tiina Leino and Ari Koivisto and Timo Viitamaa and Tarja Lehtim{\"a}ki and Antti Haapalinna and Katja Kuokkanen and Raimo Virtanen},
  journal={European journal of pharmacology},
  year={2008},
  volume={599 1-3},
  pages={65-71}
}
Alpha2-adrenergic receptors (alpha2-adrenoceptors) mediate various physiological actions of endogenous catecholamines in the central and peripheral nervous systems being involved in alertness, heart rate regulation, vasomotor control and nociceptive processing. In the present study, the pharmacological profile of a novel alpha2-adrenoceptor agonist, fadolmidine, was studied in various in vitro and in vivo assays and compared to the well characterised alpha2-adrenoceptor agonist, dexmedetomidine… CONTINUE READING

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