In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS).

@article{Thomas2012InVA,
  title={In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS).},
  author={Nicky Thomas and Ren{\'e} Holm and Anette M{\"u}llertz and Thomas Rades},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={160 1},
  pages={25-32}
}
Novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) containing the poorly water-soluble drug halofantrine above equilibrium solubility (150% S(eq)) were compared in vitro and in vivo with conventional SNEDDS containing the drug below equilibrium solubility (75% S(eq)). Pre-concentrates comprising of either medium chain lipids (Captex 300/Capmul MCM) or long chain lipids (soybean oil/Maisine), Cremophor RH40 and ethanol were formulated maintaining the lipid-to… CONTINUE READING
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