In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem.

@article{Yorgason2011InVA,
  title={In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem.},
  author={Joshua G. Yorgason and William Luxford and Federico Kalinec},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2011},
  volume={7 12},
  pages={1521-34}
}
INTRODUCTION Drug ototoxicity represents one of the main preventable causes of deafness. Ototoxicity is a trait shared by aminoglycoside and macrolide antibiotics, antimalarial medications, loop diuretics, platinum-based chemotherapeutic agents, some NSAIDs and most recently described, acetaminophen when abused with narcotic medication. These medications are prescribed despite their side effects, which includes inner ear toxicity, because they are life-saving drugs or there is a lack of better… CONTINUE READING
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