In vitro and in vivo light dose rate effects related to hematoporphyrin derivative photodynamic therapy.

@article{Gomer1985InVA,
  title={In vitro and in vivo light dose rate effects related to hematoporphyrin derivative photodynamic therapy.},
  author={Charles J. Gomer and Natalie Rucker and N J Razum and A. Linn Murphree},
  journal={Cancer research},
  year={1985},
  volume={45 5},
  pages={1973-7}
}
In vitro and in vivo experiments were performed to evaluate the parameter of light dose rate as it relates to the efficiency of hematoporphyrin derivative (HPD)-induced photosensitization. Exponentially growing Chinese hamster ovary cells were incubated with HPD (25 micrograms/ml) and were then exposed to red light (630 nm) delivered at different dose rates. A total of five dose rates (0.5, 5.0, 15, 23, and 60 milliwatts/sq cm) were examined following a 1-hr HPD incubation, two dose rates (1… CONTINUE READING