In vitro and in vivo kinetic handling of nitrite in blood: effects of varying hemoglobin oxygen saturation.

@article{Blood2007InVA,
  title={In vitro and in vivo kinetic handling of nitrite in blood: effects of varying hemoglobin oxygen saturation.},
  author={Arlin B. Blood and Gordon Power},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 3},
  pages={
          H1508-17
        }
}
Growing evidence suggests that nitrite, acting via reduction to nitric oxide by deoxyhemoglobin, may play an important role in local control of blood flow during hypoxia. To investigate the effect of hypoxia (65 Torr arterial Po(2)) on the kinetic properties of nitrite, a bolus injection of sodium nitrite (10 mg/kg iv) was given to normoxic or hypoxic newborn lambs, and the time course of plasma nitrite and methemoglobin (MetHb) concentrations was measured. The in vivo kinetics of nitrite… CONTINUE READING

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