In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery

@inproceedings{Zhang2012InVA,
  title={In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery},
  author={Xuan Zhang and Xing Liu and Tao Gong and Xun Sun and Zhirong Zhang},
  booktitle={Acta Pharmacologica Sinica},
  year={2012}
}
Aim:Dexibuprofen, the S(+)-isomer of ibuprofen, is an effective therapeutic agent for the treatment of neurodegenerative disorders. However, its clinical use is hampered by a limited brain distribution. The aim of this study was to design and synthesize brain-targeting dexibuprofen prodrugs and to evaluate their brain-targeting efficiency using biodistribution and pharmacokinetic analysis.Methods:In vitro stability, biodistribution and pharmacokinetic studies were performed on male Sprague… CONTINUE READING
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