In vitro and in vivo interactions of homocysteine with human plasma transthyretin.

@article{Lim2003InVA,
  title={In vitro and in vivo interactions of homocysteine with human plasma transthyretin.},
  author={Amareth Lim and Shantanu Sengupta and M E Mccomb and Roger Th{\'e}berge and William G. Wilson and Catherine E. Costello and Donald W. Jacobsen},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 50},
  pages={49707-13}
}
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease and an emerging risk factor for cognitive dysfunction and Alzheimer's disease. Greater than 70% of the homocysteine in plasma is disulfide-bonded to protein cysteine residues. The identity and functional consequences of protein homocysteinylation are just now emerging. The amyloidogenic protein transthyretin (prealbumin), as we now report, undergoes homocysteinylation at its single cysteine residue (Cys10) both in… CONTINUE READING