In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.

@article{Li2010InVA,
  title={In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.},
  author={Zhijie Li and F. Tan and David J. Liewehr and Seth Steinberg and Carol J. Thiele},
  journal={Journal of the National Cancer Institute},
  year={2010},
  volume={102 11},
  pages={758-70}
}
BACKGROUND Activated AKT is a marker of decreased event-free or overall survival in neuroblastoma (NB) patients. The aim of this study was to investigate the effect of perifosine, a nontoxic AKT inhibitor, as a single agent on NB cell growth in vitro and in vivo. METHODS Four human NB cell lines (AS, NGP, BE2, and KCNR) were treated with increasing concentrations of perifosine, and a quantitative analysis of cell death (apoptosis) was performed by using MTS and caspase-3/7 activity assays… CONTINUE READING