In vitro and in vivo inhibition of activation induced T cell apoptosis by bucillamine.

Abstract

OBJECTIVE To investigate the mechanism of autoimmune phenomena, occasionally seen in patients with rheumatoid arthritis treated with bucillamine (BUC) and D-penicillamine (D-Pen), by evaluating their effects on apoptosis of T cells induced by T cell receptor activation or dexamethasone. METHODS In vitro apoptosis was induced in a T cell hybridoma (SSP3.7… (More)

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