In vitro and in vivo inhibition of MRP gene expression and reversal of multidrug resistance by siRNA.

@article{Wu2011InVA,
  title={In vitro and in vivo inhibition of MRP gene expression and reversal of multidrug resistance by siRNA.},
  author={Zhuo Wu and Xiaobo Li and Yanyan Zeng and Xiaoming Zhuang and Hong Shen and Haiqing Zhu and Hongyi Liu and Hong Xiao},
  journal={Basic & clinical pharmacology & toxicology},
  year={2011},
  volume={108 3},
  pages={177-84}
}
Clinical drug resistance to chemotherapeutic agents is one of the major hindrances in the treatment of human cancers. One mechanism by which a living cell can achieve multidrug resistance (MDR) is via the active efflux of a broad range of anti-cancer drugs through the cellular membrane by MDR proteins. Over-expression of multidrug resistance-associated protein 1 (MRP1) is one of the important MDR phenotypes. RNA interference (RNAi) is a fundamental cellular mechanism for silencing gene… CONTINUE READING