In vitro and in vivo gene-transferring characteristics of novel cationic lipids, DMKD (O,O'-dimyristyl-N-lysyl aspartate) and dmke (O,O'-dimyristyl-N-lysyl glutamate)

@inproceedings{Kim2006InVA,
  title={In vitro and in vivo gene-transferring characteristics of novel cationic lipids, DMKD (O,O'-dimyristyl-N-lysyl aspartate) and dmke (O,O'-dimyristyl-N-lysyl glutamate)},
  author={Hong Sung Kim and In Ho Song and Jong Chul Kim and Eun Jeong Kim and Doo Ok Jang and Yong Serk Park},
  year={2006}
}
Abstract We chemically synthesized two different cationic lipids consisting of a core of lysine, two C-14 hydrocarbon chains, and either aspartatic acid or glutamic acid. The lipids were assigned the acronyms, DMKD and DMKE. Cationic liposomes prepared with the two different lipids were tested for their gene-transferring capabilities in various cell lines compared with that of control DOTAP liposomes. Under the same experimental conditions, the order of in vitro gene transfection efficiency was… CONTINUE READING

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