In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.

@article{Grimm2008InVA,
  title={In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.},
  author={Dirk Grimm and Joyce Siong See Lee and Lora S Wang and Tushar Desai and Bassel Akache and Theresa A Storm and Mark A. Kay},
  journal={Journal of virology},
  year={2008},
  volume={82 12},
  pages={5887-911}
}
Adeno-associated virus (AAV) serotypes differ broadly in transduction efficacies and tissue tropisms and thus hold enormous potential as vectors for human gene therapy. In reality, however, their use in patients is restricted by prevalent anti-AAV immunity or by their inadequate performance in specific targets, exemplified by the AAV type 2 (AAV-2) prototype in the liver. Here, we attempted to merge desirable qualities of multiple natural AAV isolates by an adapted DNA family shuffling… CONTINUE READING
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