In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy.

@article{Burckhardt2011InVA,
  title={In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy.},
  author={Gerhard Burckhardt and Birgitta Christina Burckhardt},
  journal={Handbook of experimental pharmacology},
  year={2011},
  volume={201},
  pages={
          29-104
        }
}
Organic anion transporters 1-10 (OAT1-10) and the urate transporter 1 (URAT1) belong to the SLC22A gene family and accept a huge variety of chemically unrelated endogenous and exogenous organic anions including many frequently described drugs. OAT1 and OAT3 are located in the basolateral membrane of renal proximal tubule cells and are responsible for drug uptake from the blood into the cells. OAT4 in the apical membrane of human proximal tubule cells is related to drug exit into the lumen and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 303 REFERENCES

Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules.

  • The Journal of pharmacology and experimental therapeutics
  • 2005
VIEW 20 EXCERPTS
HIGHLY INFLUENTIAL

Function and localization of urate transporter 1 in mouse kidney.

  • Journal of the American Society of Nephrology : JASN
  • 2004
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

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