In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin.

@article{Balasubramaniam2003InVA,
  title={In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin.},
  author={Jagdish Balasubramaniam and Shri Kant and Jayanta Kumar Pandit},
  journal={Acta pharmaceutica},
  year={2003},
  volume={53 4},
  pages={
          251-61
        }
}
The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems, which upon instillation as drops into the eye undergo a sol-gel transition in the cul-de-sac. This may result in better ocular availability of the drug. The purpose of this work was to develop an ophthalmic delivery system of the NSAID indomethacin, based on the concept of ion activated in situ… CONTINUE READING
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