In vitro and in vivo evaluation of taxol release from poly(lactic-co-glycolic acid) microspheres containing isopropyl myristate and degradation of the microspheres

@inproceedings{Wang1997InVA,
  title={In vitro and in vivo evaluation of taxol release from poly(lactic-co-glycolic acid) microspheres containing isopropyl myristate and degradation of the microspheres},
  author={Ya Min Wang and Hitoshi Sato and Isamu Horikoshi},
  year={1997}
}
Abstract This study describes the release and degradation profiles of taxol-loaded poly(lactic-co-glycolic acid) microspheres containing isopropyl myristate (IPM), namely, Taxol-IPM-PLGA-MS, in vitro and in vivo. Incorporation of IPM into the PLGA microspheres effectively increased the release of taxol from the microspheres in vitro. The molecular weight (Mol. Wt.) and copolymer ratio of lactic acid (LA) and glycolic acid (GA) displayed obvious influences on the characteristics of the… CONTINUE READING

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