In vitro and in vivo evaluation of novel interpenetrated polymer network microparticles containing repaglinide.

Abstract

Interpenetrated polymer network (IPN) microparticles of sterculia gum and sodium alginate loaded with repaglinide were developed by ionic gelation and emulsion crosslinking method. The drug entrapment efficiency was as high as 91%. FTIR and TG analyses confirmed the crosslinking and IPN formation. Microparticles have demonstrated the drug release up to 24h… (More)
DOI: 10.1016/j.ijbiomac.2014.06.011

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