In vitro and in vivo evaluation of glibenclamide in solid dispersion systems.

@article{Tashtoush2004InVA,
  title={In vitro and in vivo evaluation of glibenclamide in solid dispersion systems.},
  author={Bassam M. Tashtoush and Zubaida S Al-Qashi and Naji M. Najib},
  journal={Drug development and industrial pharmacy},
  year={2004},
  volume={30 6},
  pages={
          601-7
        }
}
The purpose of this work is to improve the dissolution and bioavailability characteristics of glibenclamide as compared to Daonil tablets (Hoechst). Solid dispersions of glibenclamide in Gelucire 44/14 (Formula 1) and in polyethylene glycol 6000 (PEG 6000) (Formula 2) were prepared by fusion method. In vitro dissolution studies showed that the dispersing systems containing glibenclamide and Gelucire 44/ 14 or PEG 6000 gave faster dissolution rates than the reference product Daonil. The in vivo… CONTINUE READING
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