In vitro and in vivo evaluation of differentially demineralized cancellous bone scaffolds combined with human bone marrow stromal cells for tissue engineering.

@article{Mauney2005InVA,
  title={In vitro and in vivo evaluation of differentially demineralized cancellous bone scaffolds combined with human bone marrow stromal cells for tissue engineering.},
  author={Joshua R Mauney and Claude Jaqui{\'e}ry and Vladimir Volloch and Michael M. G. Heberer and Ivan Martin and David L Kaplan},
  journal={Biomaterials},
  year={2005},
  volume={26 16},
  pages={3173-85}
}
Mineralized and partially or fully demineralized biomaterials derived from bovine bone matrix were evaluated for their ability to support human bone marrow stromal cell (BMSC) osteogenic differentiation in vitro and bone-forming capacity in vivo in order to assess their potential use in clinical tissue-engineering strategies. BMSCs were either seeded on bone-derived scaffolds and cocultured in direct cell-to-scaffold contact, allowing for the exposure of soluble and insoluble matrix… CONTINUE READING
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