In vitro and in vivo evaluation of a simple microemulsion formulation for propofol.

@article{Li2012InVA,
  title={In vitro and in vivo evaluation of a simple microemulsion formulation for propofol.},
  author={Guiling Li and Yating Fan and Xinru Li and Xiaoning Wang and Yanfang Li and Yan Liu and Mei Li},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={425 1-2},
  pages={53-61}
}
The aim of the present study was to develop an oil-free o/w microemulsion, composed of pluronic F68, propylene glycol and saline, which solubilized poorly soluble anesthetic drug propofol for intravenous administration. The ternary diagram was constructed to identify the regions of microemulsions, and the optimal composition of microemulsion was determined… CONTINUE READING