In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens

@article{Blasco2020InVA,
  title={In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens},
  author={L. Blasco and A. Ambroa and R. Trastoy and I. Bleriot and M. Moscoso and L. Fern{\'a}ndez-Garc{\'i}a and E. P{\'e}rez-Nadales and F. Fern{\'a}ndez-Cuenca and J. Torre-Cisneros and J. Oteo-Iglesias and A. Oliver and R. Cant{\'o}n and T. Kidd and F. Navarro and E. Mir{\'o} and {\'A}. Pascual and G. Bou and L. Mart{\'i}nez-Mart{\'i}nez and M. Tom{\'a}s},
  journal={Scientific Reports},
  year={2020},
  volume={10}
}
The emergence of multidrug resistant (MDR) pathogenic bacteria is jeopardizing the value of antimicrobials, which had previously changed the course of medical science. In this study, we identified endolysins ElyA1 and ElyA2 (GH108-PG3 family), present in the genome of bacteriophages Ab1051Φ and Ab1052Φ, respectively. The muralytic activity of these endolysins against MDR clinical isolates (Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae) was tested using the turbidity… Expand
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