In vitro and in vivo effects of zinc on cytokine signalling in human T cells.

@article{Varin2008InVA,
  title={In vitro and in vivo effects of zinc on cytokine signalling in human T cells.},
  author={Audrey Varin and Anis Larbi and George V. Z. Dedoussis and Stavroula Kanoni and Jolanta Jajte and Lothar Rink and Daniela Monti and Marco Malavolta and F. Marcellini and Eugenio Mocchegiani and Georges Herbein and Tamas Z Fulop},
  journal={Experimental gerontology},
  year={2008},
  volume={43 5},
  pages={472-82}
}
Aging is associated with changes in the immune response which are collectively called immunosenescence. The changes mainly affect the adaptive immune response and especially the T cell-mediated cellular immune response. There are a few data indicating that the cytokine signalling in T cells is altered with aging. Zinc has been specifically shown to have potent immunomodulatory effects. The aim of the present work was to study the IL-2 and IL-6 cytokine signalling and activation induced cell… CONTINUE READING
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