In vitro and in vivo effects of vitamin E on arachidonic acid metabolism in rat platelets.


Preincubating platelet-rich plasma (PRP) of vitamin E-deficient rats with RRR-alpha-tocopherol prior to the aggregation induced by collagen suspension resulted in inhibition of the formation of endoperoxide metabolites derived from endogenous arachidonic acid (AA). This inhibition was not dose dependent at concentrations above the plasma level of RRR-alpha… (More)


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