In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function.

@article{Xu2007InVA,
  title={In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function.},
  author={Meifeng Xu and Ryota Uemura and Ying Dai and Yigang Wang and Zeeshan Pasha and Muhammad Ashraf},
  journal={Journal of molecular and cellular cardiology},
  year={2007},
  volume={42 2},
  pages={441-8}
}
It is hypothesized that the protection of bone marrow stem cells (BMSCs) on ischemic myocardium might be related to the anti-apoptotic effect via paracrine mechanisms. In this study, a wide array of cytokines including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), stromal cell-derived factor-1 (SDF-1) and insulin growth factor-1 (IGF-1) were detected in the BMSCs cultured medium by ELISA. Myocyte apoptosis was assayed by DNA fragmentation and annexin-V… CONTINUE READING
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