In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines.

@article{Coyle1994InVA,
  title={In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines.},
  author={Thomas E. Coyle and St{\'e}phane Levante and Michele Shetler and Jonathan Winfield},
  journal={Journal of neuro-oncology},
  year={1994},
  volume={19 1},
  pages={25-35}
}
Gossypol is a lipid soluble polyphenolic compound isolated from cotton seed oil which has been previously shown to have antiproliferative activity in vitro against a variety of human solid tumor cell lines. It has been extensively tested in clinical trials as a male contraceptive agent and found to be well tolerated. Its mechanism of action is thought to be inhibition of cellular energy metabolism. It inhibits glycolysis through inhibition of LDH isoenzyme type 5, and it inhibits mitochondrial… CONTINUE READING
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