In vitro and in vivo cutaneous penetration and antifungal activity of naftifine.

@article{Stoughton1989InVA,
  title={In vitro and in vivo cutaneous penetration and antifungal activity of naftifine.},
  author={R B Stoughton and John Sefton and L D Zeleznick},
  journal={Cutis},
  year={1989},
  volume={44 4},
  pages={333-5}
}
The topical antifungal agent naftifine has shown considerable potency against a broad spectrum of dermatophytes. In this study, an in vitro penetration test in human cadaver skin and an in vivo tape-stripping test were used to evaluate the penetration and antifungal activity of naftifine gel 1 percent and naftifine cream 1 percent compared with other antifungal agents. In both models, Trichophyton rubrum and T. mentagrophytes were the fungal species. Results show that naftifine gel 1 percent… CONTINUE READING