In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers.

@article{Merkel2011InVA,
  title={In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers.},
  author={Olivia M Merkel and Rudolf Urbanics and P{\'e}ter Bedőcs and Zolt{\'a}n Rozsnyay and L{\'a}szl{\'o} Rosivall and Mikl{\'o}s T{\'o}th and Thomas R. Kissel and J{\'a}nos G{\'a}bor Szebeni},
  journal={Biomaterials},
  year={2011},
  volume={32 21},
  pages={4936-42}
}
Complement activation by polymeric gene and drug delivery systems has been overlooked in the past. As more reports appear in the literature concerning immunogenicity of polymers and their impact on gene expression patterns, it is important to address possible immune side effects of polymers, namely complement activation. Therefore, in this study the activity of low and high molecular weight poly(ethylene imine) and two PEGylated derivatives to induce complement activation were investigated in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

A novel tyrosine-modified low molecular weight polyethylenimine (P10Y) for efficient siRNA delivery in vitro and in vivo.

Journal of controlled release : official journal of the Controlled Release Society • 2016
View 1 Excerpt

Twin disulfides as opportunity for improving stability and transfection efficiency of oligoaminoethane polyplexes.

Journal of controlled release : official journal of the Controlled Release Society • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Similar Papers

Loading similar papers…