In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist.

@article{Maillard2002InVA,
  title={In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist.},
  author={Marc Maillard and Christine Perregaux and Catherine Centeno and Joachim Stangier and Wolfgang Wienen and H. Brunner and Michel Burnier},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={302 3},
  pages={
          1089-95
        }
}
In vitro studies have shown that telmisartan is an insurmountable angiotensin II subtype-1 (AT1) receptor antagonist. Herein, the molecular basis of this insurmountable antagonism has been investigated in vitro, and the effect of telmisartan has been compared in vivo with that of irbesartan and candesartan. Association and dissociation kinetics of telmisartan to AT1 receptors have been characterized in vitro on rat vascular smooth muscle cells (RVSMC) expressing solely the AT1 receptor subtype… CONTINUE READING
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