In vitro and in vivo characterization of [125I]iodomethyllycaconitine in the rat

@article{Navarro2002InVA,
  title={In vitro and in vivo characterization of [125I]iodomethyllycaconitine in the rat},
  author={H. Navarro and H. Xu and D. Zhong and P. Abraham and F. Carroll},
  journal={Synapse},
  year={2002},
  volume={44}
}
The in vitro and in vivo binding characteristics of [125I]iodomethyllycaconitine ([125I]iodoMLA) were determined in the rat. [125I]iodoMLA binding to rat cerebral cortex membranes was saturable and reversible and its specific binding represented approximately 70–80% of the total binding. [125I]iodoMLA labeled a single site with Kd = 1.8 ± 0.4 nM and Bmax = 68 ± 3 fmol/mg protein. Kinetic analysis revealed a t1/2 for association and dissociation of 10.5 ± 3.1 and 10.3 ± 1.6 min, respectively… Expand
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