In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity.

@article{Staats2007InVA,
  title={In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity.},
  author={Herman F Staats and S. Munir Alam and Richard M Scearce and Shaun M Kirwan and Julia Xianzhi Zhang and William M. Gwinn and Barton F. Haynes},
  journal={Infection and immunity},
  year={2007},
  volume={75 11},
  pages={5443-52}
}
Passive transfer of antibody may be useful for preexposure prophylaxis against biological agents used as weapons of terror, such as Bacillus anthracis. Studies were performed to evaluate the ability of anthrax antiprotective antigen (anti-PA) and antilethal factor (anti-LF) neutralizing monoclonal antibodies (mAbs) to protect against an anthrax lethal toxin (LeTx) challenge in a mouse model and to identify correlates of immunity to LeTx challenge. Despite having similar affinities for their… CONTINUE READING

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CORRELATES OF IMMUNITY TO ANTHRAX LETHAL TOXIN 5451 on A uust 29, 2017 by gest http/iai.asm .rg/ D ow nladed fom Ulrich

  • G. Jiang, S. B. Joshi, +8 authors R.C.R. Hwang
  • VOL. 75,
  • 2007

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