In vitro and in vivo characterization of CB-183,315, a novel lipopeptide antibiotic for treatment of Clostridium difficile.

@article{Mascio2012InVA,
  title={In vitro and in vivo characterization of CB-183,315, a novel lipopeptide antibiotic for treatment of Clostridium difficile.},
  author={Carmela T M Mascio and Lawrence I Mortin and Karen T Howland and Andrew D G Van Praagh and Shuxin Zhang and Anu Arya and Cun Lan Chuong and Chunfeng Kang and Tongchuan Li and Jared A. Silverman},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 10},
  pages={
          5023-30
        }
}
CB-183,315 is a novel lipopeptide antibiotic structurally related to daptomycin currently in phase 3 clinical development for Clostridium difficile-associated diarrhea (CDAD). We report here the in vitro mechanism of action, spontaneous resistance incidence, resistance by serial passage, time-kill kinetics, postantibiotic effect, and efficacy of CB-183,315 in a hamster model of lethal infection. In vitro data showed that CB-183,315 dissipated the membrane potential of Staphylococcus aureus… CONTINUE READING
BETA
Highly Cited
This paper has 72 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS, ESTIMATED 45% COVERAGE

73 Citations

01020'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 73 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Treatment of CDAD with oral CB-183 315: time to recurrence, relapse and re-infection rates compared with vancomycin

  • L Chesnel
  • Clin. Microbiol. Infect
  • 2012
1 Excerpt

Efficacy and safety of the lipopeptide CB-183,315 for the treatment of Clostridium difficile infection, abstr

  • H Patino
  • K-205a. Abstr. 51st Intersci. Conf. Antimicrob…
  • 2011
1 Excerpt

Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin

  • WN Al-Nassir
  • Clin. Infect. Dis
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…