In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.

@article{Aluisio2008InvitroAI,
  title={In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.},
  author={Leah E Aluisio and Brian Lord and Ann J Barbier and Ian C. Fraser and Sandy J Wilson and Jamin D. Boggs and Lisa K Dvorak and Michael A Letavic and Bruce E Maryanoff and Nicholas I. Carruthers and Pascal Bonaventure and Timothy W. Lovenberg},
  journal={European journal of pharmacology},
  year={2008},
  volume={587 1-3},
  pages={141-6}
}
Triple reuptake inhibitors, which block the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) in the central nervous system have been described as therapeutic alternatives for classical selective serotonin reuptake inhibitors, with advantages due to their multiple mechanisms of action. JNJ-7925476 (trans-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline) is a selective and potent inhibitor of the SERT, NET, and DAT (K(i)=0.9, 17… CONTINUE READING