In vitro and in vivo characterization of temoporfin-loaded PEGylated PLGA nanoparticles for use in photodynamic therapy.

@article{Rojnik2012InVA,
  title={In vitro and in vivo characterization of temoporfin-loaded PEGylated PLGA nanoparticles for use in photodynamic therapy.},
  author={Matija Rojnik and Petra Kocbek and Francesca Moret and Chiara Compagnin and Lucia Celotti and Melissa J Bovis and Josephine H. Woodhams and Alexander J. Macrobert and Dietrich Scheglmann and Wijnand Helfrich and Marco J Verkaik and Emanuele Papini and E. U. B. Reddi and Janko Kos},
  journal={Nanomedicine},
  year={2012},
  volume={7 5},
  pages={663-77}
}
AIMS In this study we evaluated temoporfin-loaded polyethylene glycol (PEG) Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) as a new formulation for potential use in cancer treatment. MATERIALS & METHODS NPs were characterized for their photophysical properties, temoporfin release, cellular uptake and intracellular localization, and dark and photocytotoxicities of temoporfin by using A549, MCF10A neoT and U937 cell lines. In vivo imaging was performed on athymic nude-Foxn1 mice… CONTINUE READING

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