In vitro and in vivo biological activity of PEDF against a range of tumors.

  title={In vitro and in vivo biological activity of PEDF against a range of tumors.},
  author={Matthew L. Broadhead and Crispin R Dass and Peter Choong},
  journal={Expert opinion on therapeutic targets},
  volume={13 12},
BACKGROUND Pigment epithelium-derived factor (PEDF) is an emerging anti-cancer agent that targets both tumor tissue and its supporting vasculature. These direct and indirect effects of PEDF have been examined in vitro and in vivo for a range of malignancies. OBJECTIVE This review seeks to present PEDF as a potential anti-cancer agent with applications across multiple malignancies. We refer closely to experimental methodology whilst still highlighting the clinical significance of PEDF in… CONTINUE READING

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